Randomized Clinical Trials

History of clinical trials

The Primary Outcome Fails – What Next?

Projects:

  1. Matched Randomization (Vanderbilt Wiki)

  2. Adaptive designs

Trials that ended prematurely:

  1. The Cardiac Insufficiency Bisoprolol Study (CIBIS) then followed up by CIBIS II

  2. Towards a Revolution in COPD Health (TORCH) (p = 0.052 on primary outcome and awkward statement that `significant benefits in all other outcomes’)

  3. Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT) (primary outcome p = 0.08)

For data-based priors: Clinical Study Data Request